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Wytensin
Side Effects:
 You
may feel tired and run down the first few weeks while taking this
medication as your body adjusts to the lower blood pressure.
This is normal.
Continue taking the medication.
If the symptoms persist or become severe, inform your doctor.Dizziness
and drowsiness are common especially during the first few weeks
of therapy
Other side effects may include headache, indigestion, nasal congestion,
decreased sexual ability, blurred vision, or sleep disturbances.
Contact your doctor if you experience breathing difficulties, tremors,
swelling of the hands or feet, chest pain or depression.
Precautions:
Tell your doctor your medical history, especially of heart, liver
or kidney problems and of any drug allergies.
Use caution performing task requiring alertness such as driving
or using machinery if this medication makes you dizzy or drowsy.
Limit or avoid alcohol because it may add to the dizziness and/or
drowsiness effects of this medication.
Elderly patients may be more sensitive to the effects of this
medication. Use cautiously.
This medication should be used only when clearly needed during
pregnancy. Discuss the risks and benefits with your doctor.
It is not known if guanabenz is excreted into breast milk.
Consult your doctor before breast-feeding.
Generic Name: Guanabenz Acetate
Related:
Wytensin 4 mg Tablet - Prescription
Guanabenz Acetate 4 mg Tablet - Prescription
Wytensin 8 mg Tablet - Prescription
Guanabenz Acetate 8 mg Tablet - Prescription
18587s23ltr
http://www.fda.gov/cder/foi/appletter/2001/18587s23ltr.pdf
drug, NDA, Drug Evaluation, Lipicky, electronic signature,
drug product, patients, younger, package, printed labeling, response.
Clinical studies of Wytensin did not include sufficient
number of subject aged 65 and over to determine whether they respond
differently from younger subjects.
Other reported clinical experience has not identified differences
in responses between the elderly and younger patients.
We have completed the review of this supplemental application, as
amended, and have concluded that adequate information has been presented
to demonstrate that the drug product is safe and effective for use
as recommended in the final printed labeling (package insert) included
in your August 17, 2001 submission.
drug_summary_tables_502-503
Adult, mg/d, Duration, Onset, t1/2, Hypertension, Unknown,
captopril, ACE inhibitors, maintenance, bid.
However, peripheral vascular resistance is lowered more
than cardiac output is increased, resulting in a significant decrease
in blood pressure.
Captopril also increases renal blood flow but has no effect on the
glomerular filtration rate.
ACE is similar to bradykinase (kinase II).
Thus, ACE inhibitors increase the levels of bradykinin, and bradykinin
stimulates the synthesis of prostaglandins.
It is contraindicated in patients with hypersensitivity to the drug,
and there may be a crosssensitivity to other ACE inhibitors.
It resolves within 1 to 4 days after therapy stops but is a major
reason for nonadherence to therapy.
Angioedema can occur after the first dose of captopril, or at any
other time during therapy.
0471274011
http://media.wiley.com/product_data/excerpt/11/04712740/0471274011.pdf
adrenergics, drugs, metabolite, norepinephrine, selectivity,
catecholamine, receptors, stimulation, agonists, agents, applications.
In both their chemical structures and biological activities,
adrenergics and adrenergicblocking agents constitute an extremely
varied group of drugs whose clinical utility includes prescription
drugs to treat lifethreatening conditions such as asthma and hypertension
as well as nonprescription medications for minor ailments such as
the common cold.
Identification of subclasses of adrenoceptors has been greatly aided
by the tools of molecular biology and, to date, six distinct -ad-renoceptors
(1A, 1B, 1D, 2A, 2B, 2C), and three distinct -adrenoceptors (1,
2, 3) have been clearly identified (1), with conflicting evidence
for a fourth type of (4) (1--3).
2.2 Absorption, Distribution, Metabolism, and Elimination Because
of the large numbers of chemicals acting as either adrenergics or
adrenergic-block-ing drugs, only representative examples will be
given and limited to metabolites identified in humans.
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